Functional preconcentration tip of total volume injection for ESI/MS analysis of DNA adducts.

نویسندگان

  • Hiroya Murakami
  • Mio Koguchi
  • Yukihiro Esaka
  • Bunji Uno
  • Yasushi Ishihama
چکیده

We have developed a simple method to significantly improve the sensitivity in the LC/MS analysis of DNA adducts. A preconcentration tip for the selective recovery of DNA adducts was prepared. Using this tip, the total amount of DNA adducts in a treated DNA sample was injected in a one-shot manner into an LC/MS system. We were able to improve the sensitivity by more than one order of magnitude in concentration. This method will be a useful tool for the quantitative determination of trace DNA adducts.

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عنوان ژورنال:
  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

دوره 27 2  شماره 

صفحات  -

تاریخ انتشار 2011